Maybe.
Yes, if you are constructively and professionally questioning a decision or directive made by a higher-up that does not seem to be in the best business interest of the project, client, or company. Make sure your argument is fact-based and delivered in a respectful manner, offers specific alternatives, and leaves the impression that you want what’s best for the business.
Yes, if the decision or directive appears to be unlawful or unethical.
No, if senior management has concluded the discussion is over and it is time to implement the decision. Your opinion may differ from a higher-up’s, but that doesn’t necessarily mean that you are right or your superior is wrong.